Ronald Colman as The Spirit of Man

Hedy Lamarr as Joan of Arc

Groucho Marx as Peter Minuit

Harpo Marx as Sir Isaac Newton

Chico Marx as Monk

Virginia Mayo as Cleopatra

Agnes Moorehead as Queen Elizabeth I

Vincent Price as Mr. Scratch / The Devil

Peter Lorre as Nero

Charles Coburn as Hippocrates

Cedric Hardwicke as High Judge

Cesar Romero as Spanish Envoy

John Carradine as Khufu

Dennis Hopper as Napoleon Bonaparte

Marie Wilson as Marie Antoinette

Helmut Dantine as Marc Antony

Edward Everett Horton as Sir Walter Raleigh

Reginald Gardiner as William Shakespeare

Marie Windsor as Josephine Bonaparte

George E. Stone as Waiter

Cathy O'Donnell as Early Christian Woman

Franklin Pangborn as Marquis de Varennes

Melville Cooper as Major Domo

Henry Daniell as Pierre Cauchon - Bishop of Beauvais

Francis X. Bushman as Moses

Jim Ameche as Alexander Graham Bell

Nick Cravat as Devil's Apprentice

David Bond as Early Christian

Dani Crayne as Helen of Troy

Richard H. Cutting as Court Attendant

Anthony Dexter as Christopher Columbus

Melinda Marx as Early Christian Child

Don Megowan as Early Man

Austin Green as Abraham Lincoln

Reginald Sheffield as Julius Caesar

Bobby Watson as Adolf Hitler

Creighton Hale as Heavenly Judge

Angelo Rossitto as Dwarf in Nero's Court

Marvin Miller as Amarna

Ziva Rodann as Egyptian Concubine