Dennis Quaid as Jack Hall

Jake Gyllenhaal as Sam Hall

Emmy Rossum as Laura Chapman

Dash Mihok as Jason Evans

Jay O. Sanders as Frank Harris

Sela Ward as Dr. Lucy Hall

Austin Nichols as J.D.

Arjay Smith as Brian Parks

Tamlyn Tomita as Janet Tokada

Sasha Roiz as Parker

Ian Holm as Terry Rapson

Richard McMillan as Dennis

Nassim Sharara as Saudi Delegate

Carl Alacchi as Venezuelan Delegate

Kenneth Welsh as Vice President Becker

Michel 'Gish' Abou-Samah as Saudi Translator

Kenneth Moskow as Bob

Glenn Plummer as Luther

Adrian Lester as Simon

Nestor Serrano as Gomez

John Maclaren as Veteran Scientist

Richard Zeman as Flight Director

Perry King as President Blake

Mimi Kuzyk as Secretary of State

Vitali Makarov as Yuri, Russian Astronaut

Russell Yuen as Hideki, Japanese Astronaut

Tim Bagley as Tommy

Chris Britton as Vorsteen

Christian Tessier as Aaron

Rick Hoffman as NY Businessman on Bus

Alan Fawcett as Commander Daniels

Sheila McCarthy as Judith

Amy Sloan as Elsa

Karen Glave as Maria

Joe Cobden as Zack

Caroline Keenan as Tina

Matt Adler as Truck Radio Announcer (voice)

Nobuya Shimamoto as Japanese Policeman

Robin Wilcock as Tony

Jesus Perez as Mexican (NWS) Janitor

Wendy L. Walsh as Weather Channel Newscaster #1