Jennifer Lopez as Lauren Adrian

Martin Sheen as George Morgan

Antonio Banderas as Alfonso Diaz

Maya Zapata as Eva Jimenez

Sônia Braga as Teresa Casillas

Kate del Castillo as Elena Diaz

Randall Batinkoff as Frank Kozerski

Juan Diego Botto as Marco Antonio Salamanca

Irineo Alvarez as Domingo Esparza

Julio Cesar Cedillo as Julio

Zaide Silvia Gutiérrez as Lourdes Jimenez

Rene Rivera as Aris Rodriguez

Karolinah Villarreal as Young Lauren

Debrianna Mansini as Flight Attendant

J.D. Garfield as Doctor Herrera

Juanes as Himself

Teresa Ruiz as Cecilia Rojas

Marilyn Dodds Frank as Donna Mackenzie

Paul Blott as Samuel Denton

Doris Hargrave as Secretary

Amelia Zapata as Lourdes's Friend

Peter Gonzales Falcon as Police Chief

John Norman as Senator Rawlings

Gonzalo Mauro Montiel Aguirre as Curandero

Mike Campos as Police Man

Jorge Urzua as Eduardo Lopes

Ruben G. Rojas as Eduardo's Man

Irene Estrada as Teresa's Maid

Deborah Martinez as Victim's Mother

Eduardo Garza as Arturo

Miguel Piliado as Coyote #1

Héctor Zavala as Coyote #2

Ronald Robert Hamilton as Father (uncredited)

Arlin Alcala as Aunt (uncredited)

Brandon Smith as Mr. Adrian (uncredited)