Gary Cooper as Wild Bill Hickok

Jean Arthur as Calamity Jane

James Ellison as William "Buffalo Bill" Cody

Charles Bickford as John Lattimer

Helen Burgess as Louisa Cody

Porter Hall as Jack McCall

Paul Harvey as Yellow Hand

Victor Varconi as Painted Horse

John Miljan as General George A. Custer

Frank McGlynn Sr. as Abraham Lincoln

Granville Bates as Van Ellyn

Anthony Quinn as Cheyenne Indian

George 'Gabby' Hayes as Breezy

Mark Strong as Wells Fargo Agent (uncredited)

Frank Albertson as A Young Trooper

Purnell Pratt as Capt. Wood

Fred Kohler as Jake - A Teamster

Pat Moriarity as Sgt. McGinnis

Charles Judels as Tony - The Barber

Harry Woods as Quartermaster Sergeant

Francis McDonald as A River Gambler

George Ernest as A Boy

George MacQuarrie as Gen. Merritt

Fuzzy Knight as Dave

Everett Brown as

Curtis Nero as Roustabout