Ryan Reynolds as Detective Pikachu (voice)

Justice Smith as Tim Goodman

Kathryn Newton as Lucy Stevens

Suki Waterhouse as Ms. Norman

Omar Chaparro as Sebastian

Chris Geere as Roger Clifford

Rita Ora as Dr. Ann Laurent

Karan Soni as Jack

Josette Simon as Grams

Ken Watanabe as Lieutenant Hide Yoshida

Bill Nighy as Howard Clifford

Alejandro De Mesa as Bartender

Max Fincham as Young Tim Goodman

Simone Ashley as Girlfriend

Edward Davis as Boyfriend

Diplo as DJ

Ben Fox as Lead Cop

Kadiff Kirwan as Mayor

Ryoma Takeuchi as Male Pokémon Trainer

Rina Hoshino as Mewtwo (voice)

Kotaro Watanabe as Mewtwo (voice)

Ikue Otani as Pikachu (voice)

Sofia Abbasi as Parade Attendee - Ryme City Citizen