Ryan Reynolds as Detective Pikachu (voice)

Justice Smith as Tim Goodman

Kathryn Newton as Lucy Stevens

Bill Nighy as Howard Clifford

Ken Watanabe as Lieutenant Hide Yoshida

Chris Geere as Roger Clifford

Suki Waterhouse as Ms. Norman

Josette Simon as Grams

Alejandro De Mesa as Bartender

Rita Ora as Dr. Ann Laurent

Karan Soni as Jack

Max Fincham as Young Tim Goodman

Simone Ashley as Girlfriend

Edward Davis as Boyfriend

Diplo as DJ

Omar Chaparro as Sebastian

Ben Fox as Lead Cop

Kadiff Kirwan as Mayor

Ryoma Takeuchi as Male Pokémon Trainer

Rina Hoshino as Mewtwo (voice)

Kotaro Watanabe as Mewtwo (voice)

Ikue Otani as Pikachu (voice)

David Errigo Jr. as Cubone (voice)

Sean Chiplock as Roundhouse Arena Announcer / Train PA System (voice)

Rachael Lillis as Jigglypuff (voice)