Rainn Wilson as Frank Darbo

Elliot Page as Libby

Liv Tyler as Sarah

Kevin Bacon as Jacques

Gregg Henry as Detective John Felkner

Michael Rooker as Abe

Andre Royo as Hamilton

Sean Gunn as Toby

Stephen Blackehart as Quill

Linda Cardellini as Pet Store Employee

Nathan Fillion as The Holy Avenger

Don Mac as Mr. Range

Gerardo Davila as Cop

Grant Goodman as Young Frank

Paul T. Taylor as Frank Sr.

Connor Day as Teenage Frank

James Gunn as Demonswill

Mikaela Hoover as Holly

Nick Holmes as Jim

Matt Moore as Jesus / Guy In Line

Rob Zombie as Voice Of God (voice)

Steve Agee as Comic Book Store Jerk

Laurel Whitsett as Librarian

James Lentzsch as Passenger Teen

Nate Rubin as Driving Teen

Edrick Browne as Nathaniel

Danny Cosmo as Purse-snatcher

Krystal Mayo as Wheelchair Woman

Russell Towery as Chickenhawk

Mario Jiminez Jr. as Chicken

Jonathan Winkler as Transvestite

Mollie Milligan as Sarah's Sister

Gerry May as Newscaster

Valentine Miele as Line Butter

Michelle Gunn as Line Butter's Girlfriend

Darcel White Moreno as Waitress

Greg Ingram as Long-haired Hood

Lindsay Soileau as Libby's Friend

Brandon Belknap as Christian

Zach Gilford as Jerry

Lloyd Kaufman as 911 Man

Tim J. Smith as Range's Technician

Mark De Alessandro as Thug Jumped On By Boltie

Cole S. McKay as Thug Set On Fire

Dominick LaBanca as Thug #1

John W. Lawson as Thug Missing Arms

William Katt as Sgt. Fitzgibbon

Christine Bently as Stoner Girl