Ron Perlman as Hellboy

Selma Blair as Liz Sherman

Doug Jones as Abe Sapien / Chamberlain / Angel of Death

John Alexander as Johann Krauss / Bethmoora Goblin

Seth MacFarlane as Johann Krauss (voice)

Luke Goss as Prince Nuada

Anna Walton as Princess Nuala

Jeffrey Tambor as Tom Manning

John Hurt as Trevor Bruttenholm

James Dodd as Johann Krauss

Brian Steele as Wink / Cronie / Spice Shop Troll / Cathedral Head / Fragglewump

Andrew Hefler as Agent Flint

Iván Kamarás as Agent Steel

Mike Kelly as Agent Marble

Jeremy Zimmermann as Auctioneer

Santiago Segura as Distinguished Buyer

Roy Dotrice as King Balor

Aidan Cook as Two-Headed Shop Owner

Jeanne Mockford as Bag Lady

Montse Ribé as Young Hellboy

Ferenc Elek as Fat Slob

Alex McSweeney as Policeman

Justin Pierre as Policeman

Matthew O'Toole as Limb Vendor

Jamie Wilson as Cat Vendor

Clive Llewellyn as Tadpole Vendor

Sándor Svigelj as Bagpipe Player

Brian Herring as Silkard / Fish Vendor

Pálma Pásztor as Mummy Vendor

Jimmy Kimmel as Jimmy Kimmel

Tim Flavin as Newscaster

Belinda Henley as Newscaster

Blake Perlman as Newscaster

Matt Rippy as Newscaster

Judit Viktor as Lady with Dog

Szonja Oroszlán as Woman with Baby

Michael Mehlmann as Auction Bidder Man

Todd Williams as Auction Bidder Man

Beatrice Zentai as Auction Bidder Woman

Peter Horkay as Steward

Richard Rifkin as TV Pundit

Guillermo del Toro as Creature Vocals (voice) (uncredited)

Tim Larsen as Street Thug (uncredited)

Gavin McKenzie as Auction Room Steward (uncredited)

Julia Papp as Reporter (uncredited)