Ben Stiller as Derek Zoolander (voice)

Owen Wilson as Hansel (voice)

Patton Oswalt as Dr. Botoxo (voice)

Jenny Slate as Nani (voice)

Nick Kroll as Frankie J-PEG (voice)

Tim Gunn as Tim Gunn (voice)

Christine Taylor as Matilda Jeffries (voice)

Jerry Stiller as Maury Ballstein (voice)

Rashida Jones as D'Jangelo (voice)

Andy Daly as Nani's Dad (voice)

Julie Klausner as (voice)

Jon Daly as The Paparocto (voice)

James Adomian as (voice)

Leighton Meester as Leighton Meester (voice)

Heidi Klum as Heidi Klum (voice)

Kim Kardashian as Kim Kardashian (voice)

Khloé Kardashian as Khloé Kardashian (voice)

Katy Perry as Katy Perry (voice)