Philip Seymour Hoffman as Caden Cotard

Samantha Morton as Hazel

Michelle Williams as Claire Keen

Catherine Keener as Adele Lack

Emily Watson as Tammy

Dianne Wiest as Ellen Bascomb / Millicent Weems

Jennifer Jason Leigh as Maria

Hope Davis as Madeleine Gravis

Tom Noonan as Sammy Barnathan

Sadie Goldstein as Olive (4 years old)

Robin Weigert as Adult Olive

Deirdre O'Connell as Ellen's Mother

Alice Drummond as Actress Playing Frances

Amy Wright as Burning House Realtor

Elizabeth Marvel as Warehouse Realtor

Christopher Evan Welch as Pastor

Charles Techman as Like Clockwork Patient

Tom Greer as Medic

Josh Pais as Ophthalmologist

Lynn Cohen as Caden's Mother

Jerry Adler as Caden's Father

Daisy Tahan as Ariel

Frank Girardeau as Plumber

Kristen Bush as Actress Playing Claire

Stanley Krajewski as Actor as Caden

Peter Friedman as Emergency Room Doctor

Daniel London as Tom

Robert Seay as David

Stephen Adly Guirgis as Davis

Joe Lisi as Maurice

Michael Medeiros as Eric

William Ryall as Jimmy

Rosemary Murphy as Frances

John Rothman as Dentist

Paul Sparks as Derek

Tim Guinee as Needleman Actor

Michael Higgins as Actor Playing Man with Nose Bleed

Barbara Haas as Warehouse Actress

Greg McFadden as Actor Playing Needleman Actor

Alvin Epstein as Man with Nose Bleed

Gerald Emerick as Man in Line

Chris McGinn as Lady at Caden's Mom's

Dan Ziskie as Leg Tremor Doctor

Portia as Therapy Patient Actress

Nicholas Wyman as Soap Actor Doctor

Amy Spanger as Soap Actress Nurse

Timothy Doyle as Michael

Cliff Carpenter as Old Man

Raymond Angelic Sr. as German Doctor

Erica Fae as German Woman

Mark Lotito as Minister

Laura Odeh as Toystore Clerk

Deanna Storey as Jazz Singer

Frank Wood as Evaluative Services Doctor

Amanda R. Phillips as Emergency Room Nurse

Kat Peters as Ellen (10 years old)