Nicolas Cage as Charlie Kaufman / Donald Kaufman

Meryl Streep as Susan Orlean

Chris Cooper as John Laroche

Tilda Swinton as Valerie Thomas

Jay Tavare as Matthew Osceola

Litefoot as Russell

Roger Willie as Randy

Jim Beaver as Ranger Tony

Cara Seymour as Amelia Kavan

Doug Jones as Augustus Margary

Gary Farmer as Buster Baxley

Peter Jason as Defense Attorney

Gregory Itzin as Prosecutor

Curtis Hanson as Orlean's Husband

Agnes NaDene Baddoo as Orlean Dinner Guest

Paul Fortune as Orlean Dinner Guest

Paul Jasmin as Orlean Dinner Guest

Lisa Love as Orlean Dinner Guest

Wendy Mogel as Orlean Dinner Guest

David O. Russell as Orlean Dinner Guest

Judy Greer as Alice the Waitress

Maggie Gyllenhaal as Caroline Cunningham

Bob Stephenson as David

Bob Yerkes as Charles Darwin

Lynn Court as Laroche’s Dad

Roger E. Fanter as Laroche’s Uncle

Sandra Lee Gimpel as Laroche’s Mom

Caron Colvett as Laroche’s Wife

Larry Krask as EMT

Ron Livingston as Marty Bowen

Brian Cox as Robert McKee

John Etter as McKee Lecture Attendee

Ray Berrios as Police Officer

Nancy Lenehan as Kaufman’s Mother

John Cusack as John Cusack (uncredited)

Catherine Keener as Catherine Keener (uncredited)

John Malkovich as John Malkovich (uncredited)

Curt Clendenin as Restaurant Customer (uncredited)

Donald Dowd as Cafe Customer (uncredited)