Hugh Grant as The Prime Minister

Alan Rickman as Harry

Emma Thompson as Karen

Liam Neeson as Daniel

Martine McCutcheon as Natalie

Colin Firth as Jamie Bennett

Bill Nighy as Billy Mack

Laura Linney as Sarah

Lúcia Moniz as Aurelia

Andrew Lincoln as Mark

Keira Knightley as Juliet

Chiwetel Ejiofor as Peter

Gregor Fisher as Joe

Martin Freeman as John

Joanna Page as Just Judy

Heike Makatsch as Mia

Thomas Brodie-Sangster as Sam

Kris Marshall as Colin Frissell

Rodrigo Santoro as Karl

Abdul Salis as Tony

Rowan Atkinson as Rufus, Jewellery Salesman

Rory MacGregor as Engineer

Sienna Guillory as Jamie's Girlfriend

Billy Bob Thornton as The US President

Lulu Popplewell as Daisy, Karen's Daughter

Olivia Olson as Joanna Anderson

Nina Sosanya as Annie

Frank Moorey as Terence, Who's in Charge

Jill Raymond as Pat the Housekeeper

Tim Hatwell as Vicar

Lynden David Hall as The Wedding Singer

Jont Whittington as Guitarist

Dan Fredenburgh as Jamie's Bad Brother

Julia Davis as Nancy the Caterer

Alan Barnes as Movie Director

Shaughan Seymour as Movie Cameraman

Helen Murton as Funeral Priest

Edward Hardwicke as Sam's Grandfather

Caroline John as Sam's Grandmother

Gemma Aston as Family Mourner

Matt Harvey as Family Mourner

Adrian Preater as Family Mourner

Joanna Thaw as Family Mourner

Junior Simpson as Wedding DJ

Brian Bovell as Radio Watford DJ

Sarah McDougall as Receptionist

Marcus Brigstocke as Mikey, DJ Interviewer

Richard Hawley as Alex, Deputy Prime Minister

Wyllie Longmore as Jeremy

Gillian Barge as Cabinet Minister

Richard Cotton as Cabinet Minister

Kate Bowes Renna as Cabinet Minister

Kate Glover as Cabinet Minister

Nicola McRoy as Cabinet Minister

Anthony McPartlin as Ant

Declan Donnelly as Dec

Elisabeth Margoni as Eleonore

Peter Marinker as US Expert

Keir Charles as Press Conference Reporter

Doraly Rosen as Press Conference Reporter

Meg Wynn Owen as PM's Secretary

Carol Carey as Natalie's Replacement

Jo Whiley as Radio DJ

Sarah Atkinson as Billy's Video Vixen

Clare Bennett as Billy's Video Vixen

Sarah Holland as Billy's Video Vixen

Vicki Murdoch as Billy's Video Vixen

Meredith Ostrom as Billy's Video Vixen

Katherine Poulton as Billy's Video Vixen

Tuuli Shipster as Billy's Video Vixen

Michael Parkinson as Parky

Michael Fitzgerald as Michael, Sarah's Brother

Ciaran O'Driscoll as Hospital Patient

William Wadham as Bernie, Karen's Son

Catia Duarte as Language Student

Igor Urdenko as Language Student

Nat Udom as Language Student

Ines Boughanmi as Language Student

Yuk Sim Yau as Language Student

John Sharian as Wisconsin Taxi Driver

Glenn Conroy as Barman

Ivana Miličević as Stacey, American Dreamgirl

January Jones as Jeannie, American Angel

Elisha Cuthbert as Carol-Anne, American Goddess

Wes Butters as Radio 1 Chart Show DJ

Laura Rees as Record Company Executive

Emma Buckley as Jamie's Sister

Sheila Allen as Jamie's Mum

Terry Reece as PM's Chauffeur, Terry

Colin Coull as PM's Bodyguard, Gavin

Margery Mason as Harris Street Old Lady

Katharine Bailey as Harris Street Little Girl

Tiffany Boysell as Her Friend

Georgia Flint as Her Friend

Joanna Bacon as Natalie's Mum

Bill Moody as Natalie's Dad

Billy Campbell as Natalie's Octopus Brother

Paul Slack as John's Brother

Adam Godley as Mr Trench

Ruby Turner as Mrs. Jean Anderson

Amanda Garwood as Backing-singer Teacher

Arturo Venegas as Mr. Anderson

Claudia Schiffer as Carol

Patrick Delaney as Tommy, Carol's Son

Helder Costa as Mr. Barros

Carla Vasconcelos as Sophia Barros

Stewart Howson as Airport Gate Man

Jamie Edgell as Airport Guard

Dave Fisher as Airport Guard

Paul Heasman as Airport Guard

Tony Lucken as Airport Guard

Raul Atalaia as Restaurant Proprietor

Nancy Sorrell as Greta

Shannon Elizabeth as Harriet, the Sexy One

Denise Richards as Carla, the Real Friendly One

Richard Curtis as Trombone Player (uncredited)

Frances de la Tour as Lesbian Lover (uncredited)

Rebecca Frayn as Joanna (Daniel's Dead Wife) (uncredited)

Kelly Michelle Gray as Journalist (uncredited)

Nia Jermin as Head Chorister (uncredited)

Jeanne Moreau as Taxi Passenger at Marseille Airport (uncredited)

Deanna Mustard as Airport Attendant (uncredited)

Anne Reid as Headmistress (uncredited)

Fiona Thompson as Passenger Arriving at Airport (uncredited)