Peter Falk as Columbo

Gene Barry as Dr. Ray Flemming

Katherine Justice as Joan Hudson

William Windom as Burt Gordon

Nina Foch as Carol Flemming

Virginia Gregg as Miss Petrie

Andrea King as Cynthia Gordon

Susanne Benton as The Blonde

Ena Hartman as Nurse

Sherry Boucher as Air Hostess

Anthony James as Tommy

Frank Baker as Man in Park (uncredited)

Jim Creech as Policeman in Hospital (uncredited)

Ed Haskett as Party Guest (uncredited)

Clark Howat as Doctor (uncredited)

Mark Russell as Policeman (uncredited)

Don Stewart as Airline Ticket Man (uncredited)

Tom Williams as Laundry Delivery Man (uncredited)