Jared Leto as Dr. Michael Morbius

Matt Smith as Milo

Adria Arjona as Martine Bancroft

Jared Harris as Dr. Emil Nicholas

Tyrese Gibson as Agent Simon Stroud

Al Madrigal as Agent Rodriguez

Michael Keaton as Adrian Toomes

Zaris-Angel Hator as Anna

Joe Ferrara as Bush Pilot

Charlie Shotwell as Young Michael

Joseph Esson as Young Milo

Jason Rennie as Ringleader Bully

Aryan Moaven as Gang Member

Christopher Louridas as Gang Member

Oliver Bodur as Gang Member

Tom Forbes as Finance Bro (Pub)

Clara Rosager as Jean (Pub)

Corey Johnson as Mr. Fox

Rolan Bell as Private Security Professional

Bentley Kalu as Private Security Professional

Joanna Burnett as Nurse Kristen Sutton

Fermin Galeano as Bodega Owner

Maia Scalia as Diner Cashier

Archie Renaux as Bobby

Jojo Macari as Gabriel

Abraham Popoola as Ryan

Adam El Hagar as Beat Cop

Apphia Campbell as ESU Officer (Detention Center)

Barry Aird as Newspaper Vendor

Kalle Hennie as Norwegian Bodyguard

Chris Ryman as Officer Dyson

Jay Gomez-Adams as Construction Worker

Robert Ryan as Kite Flyer (uncredited)

Philip Gascoyne as NY Businessman (uncredited)