Eric Stoltz as Lester Grimm, aka Vince

Annabella Sciorra as Ramona Ray

Chris Eigeman as Dashiell Frank

Carlos Jacott as Vince, aka Leo

Marianne Jean-Baptiste as Lucretia

Brian Kerwin as Stephen

John Lehr as Lint

Peter Bogdanovich as Dr. Howard Poke

Vincent Polidoro as Young Lester Grimm

Yvette Brooks Grant as Paulina

Jose Soto as Club Promoter

Delaine Yates as Ariana

Nico Baumbach as Ex-Boyfriend

Joel Kastelberg as Curt

Dean Wareham as Music Video Director

Leigh Zimmerman as Lois

Patricia Towers as Museum Woman

Helen Hanft as Millie

Andrew Mills as Trey

James P. Engel as Harold

Martha Gehman as Josselyn

Lauren Katz as Maria

Michelle Blakely as Imogen

Matthew Kaplan as Omar

Jonathan Baumbach as Marlon

Julie Jacott as Amy

Noah Baumbach as Arliss

Eddie Kaye Thomas as Nat

Bridget Fonda as Irene

Laurie Durning as Waitress

Christopher Reed as Male Classmate