Christine Cavanaugh as Charles 'Chuckie' Finster Jr. (voice)

Cheryl Chase as Angelica C. Pickles (voice)

Kath Soucie as Phillip 'Phil' DeVille/Lillian 'Lil' DeVille/Elizabeth 'Betty' DeVille (voice)

Tara Strong as Dylan Prescott 'Dil' Pickles (voice)

Cree Summer as Susan 'Susie' Carmichael (voice)

Tress MacNeille as Charlotte C. Pickles (voice)

Melanie Chartoff as Didi Pickles (voice)

Jack Riley as Stu Pickles (voice)

Joe Alaskey as Louis 'Grandpa' Pickles (voice)

Michael Bell as Drew Pickles/Charles 'Chaz' Finster, Sr. (voice)

Charlie Adler as Professor Spooky (voice)

E. G. Daily as Tommy Pickles (voice)