Kristen Wiig as Annie Walker

Maya Rudolph as Lillian Donovan

Rose Byrne as Helen Harris

Chris O'Dowd as Officer Rhodes

Wendi McLendon-Covey as Rita

Ellie Kemper as Becca

Melissa McCarthy as Megan Price

Jon Hamm as Ted

Jill Clayburgh as Judy Walker

Rebel Wilson as Brynn

Matt Lucas as Gil

Michael Hitchcock as Don Cholodecki

Tim Heidecker as Douglas Price

Franklyn Ajaye as Mr. Donovan

Lynne Marie Stewart as Mrs. Donovan

Terry Crews as Rodney

Jessica St. Clair as Whitney

Kali Hawk as Kahlua

Andy Buckley as Helen's Husband

Matt Bennett as Helen's Stepson

Nancy Carell as Helen's Tennis Partner

Melanie Hutsell as Carol

Carnie Wilson as Carnie Wilson

Chynna Phillips as Chynna Phillips

Wendy Wilson as Wendy Wilson

Joe Nuñez as Oscar

Mia Rose Frampton as Jewelry Store Girl

Tom Yi as Jewelry Store Couple

Elaine Kao as Jewelry Store Couple

Mitch Silpa as Flight Attendant Steve

Dana Powell as Flight Attendant Claire

Greg Tuculescu as Kevin

Brian Petsos as Pete

Ben Falcone as Air Marshall Jon

Richard Riehle as Bill Cozbi

Suzanne LaChasse as Hostess (uncredited)

Annie Mumolo as Nervous Woman on Plane

Jillian Bell as Girl at Shower

Ariane Price as Girl at Shower

Paul Feig as Wedding Guest (uncredited)

Steve Bannos as Annie's Mistaken Husband

Hugh Dane as Annie's Mistaken Fella

Eloy Casados as Churra Chi Waiter

Molly Buffington as Helen's Stepdaughter

Blake Garrett Rosenthal as Tyler (as Blake Garrett)

Angelica Acedo as Flight Attendant in Coach

Joel Madison as 13-Year-Old Girl's Father

R.F. Daley as Butler

Jordan Black as Horseman

David Hoffman as Doorman at Shower

Frederik Hamel as Shower Waiter

Jimmy Brogan as Minister

Pat Carroll as Old Woman in Car (uncredited)

Owen Daniels as Obnoxious Ice Skater (uncredited)

Greg Worswick as Valet (uncredited)

Joyce Lakin as Lillian's Aunt (uncredited)

Tony Sagastizado I as Brazilian Waiter (uncredited)