Will Smith as Capt. James West

Kevin Kline as U.S. Marshal Artemus Gordon / President Grant

Kenneth Branagh as Dr. Arliss Loveless

Salma Hayek Pinault as Rita Escobar

M. Emmet Walsh as Coleman

Ted Levine as General 'Bloodbath' McGrath

Frederique van der Wal as Amazonia

Musetta Vander as Munitia

Sofia Eng as Miss Lippenrieder

Garcelle Beauvais as Belle

Bai Ling as Miss East

Rodney A. Grant as Hudson

E.J. Callahan as Mr. Pinkerton

Debra Christofferson as Dora Look-Alike

Buck Taylor as Cross-Eyed Reb

James Lashly as Reb #1

Dean Rader Duval as Reb #2

Jerry Wills as Other Reb

Mike H. McGaughy as Big reb

Christian Aubert as French Dignitary

Orestes Matacena as Spanish Dignitary

Ian Abercrombie as British Dignitary

Ismael 'East' Carlo as Mexican Dignitary

Bob Rumnock as White House Aide

Gary Carlos Cervantes as Dr. Guillermo Escobar

Jerry Potter as George Washington

Mik Scriba as Guard

Michael Sims as Prof. Thaddeus Morton

J.J. Perry as Shovel Guy (uncredited)

Dennis Keiffer as Wrench Guy (uncredited)

Derek Mears as Metal Head (uncredited)