Darren Criss as Kal-El / Clark Kent / Superman (voice)

Zachary Quinto as Lex Luthor (voice)

Ike Amadi as J'onn J'onzz / Martian Manhunter (voice)

Eugene Byrd as Ron Troupe (voice)

David Chen as Med Student / Scientist (voice)

Alexandra Daddario as Lois Lane (voice)

Brett Dalton as Parasite / Rudy Jones (voice)

Neil Flynn as Jonathan Kent (voice)

Ryan Hurst as Lobo (voice)

Cissy Jones as Nurse (voice)

Piotr Michael as Perry White (voice)

Cristina Milizia as Maya / Petey / Kaylie (voice)

April Stewart as Mrs. Ross (voice)

Bellamy Young as Martha Kent (voice)