Jason Isaacs as Superman (voice)

Amy Acker as Lois Lane (voice)

Diedrich Bader as Lex Luthor (voice)

Vanessa Marshall as Diana / Wonder Woman (voice)

Phil Morris as James Olsen (voice)

Paul Williams as Brainiac (voice)

Greg Chun as Ambassador Lee (voice)

Roger Craig Smith as Batman (voice)

William Salyers as Joseph Stalin / Jack Ryder (voice)

Jim Meskimen as John F. Kennedy / Dwight D. Eisenhower (voice)

Sasha Roiz as Hal Jordan (voice)

Phil LaMarr as John Stewart / Ron Troupe / Gulag Guard (voice)

Travis Willingham as Superior Man / Guy Gardner / Petrovich (voice)

Winter Ave Zoli as Svetlana (voice)

Jim Ward as George Taylor (voice)

Jason Spisak as Dimitri (voice)

Tara Strong as Young Superman (voice)

Anna Vocino as Tour Guide (voice)