Guillaume Canet as Astérix

Gilles Lellouche as Obélix

Vincent Cassel as Jules César

Jonathan Cohen as Graindemaïs

Julie Chen as Princesse Fu Yi

Leanna Chea as Tat Han

Marion Cotillard as Cléopâtre / Bibine

José Garcia as Biopix

Zlatan Ibrahimović as Antivirus

Manu Payet as Ri Qi Qi

Ramzy Bedia as Epidemaïs

Bun-hay Mean as Deng Tsin Qin

Linh-Dan Pham as L'Impératrice

Pierre Richard as Panoramix

Gérard Darmon as Le narrateur (voice)

Tran Vu Tran as Prince du Deng

Philippe Katerine as Assurancetourix

Jérôme Commandeur as Abraracourcix

Audrey Lamy as Bonnemine

Franck Gastambide as Le capitaine Barbe-Rouge

Vincent Desagnat as Perfidus

Orelsan as Titanix

Laura Felpin as Carioca

Issa Doumbia as Baba, la vigie des pirates

Thomas VDB as Sinus

Marc Fraize as Plexus

Florian Ordoñez as Abdelmalix

Olivio Ordonez as Toufix

David Coscas as Radius

Raphaël Carlier as Cubitus

Tatiana Gousseff as Iélosubmarine

Yann Papin as Abribus

Angèle as Falbala

Matthieu Chedid as Remix

Jason Chicandier as Ordralfabétix

Samuel Hibon as Lapsus

Marc Hoang as Ramoli

Philippe Canet as Agecanonix

Florent Manaudou as Tabascos

Ted Etienne as

Ragnar Le Breton as

Wesley Weigel as Pirate

Sakhone Holaphong as Chinese villager

André Kalmes as Cétautomatix