Elisabeth Shue as Dr. Elizabeth Barnes

Sarah Roemer as Madison Walker

Imogen Poots as Alexis

Taryn Manning as Margaret

Frances Conroy as Dolly

Erin Kelly as Grace

Wendy Glenn as Angel

Shanna Forrestall as Mental Hospital Nurse

Dominique DuVernay as Pedestrian

Samantha Beaulieu as Shante

McKinley Freeman as Henry

Douglas M. Griffin as John

Jeff Galpin as Orderly #1

Conner Ann Waterman as Young Madison

Tiffany Lynn Rowe as Angel

Chris Fry as Landlord