Matt Dillon as Regret

Jennifer Grey as Lovey Lou

Julie Hagerty as Harriet MacKyle

Rutger Hauer as The Brain

Madonna as Hortense Hathaway

Esai Morales as Handsome Jack

Anita Morris as Miss Missouri Martin

Randy Quaid as Feet Samuels

Josef Sommer as Waldo Winchester

Alan Ruck as John Wangle

Dinah Manoff as Maud Milligan

Ethan Phillips as Basil Valentine

Stephen McHattie as Red Henry

Tony Longo as Crunch Sweeney

Fisher Stevens as Hotfoot Harry

Richard Edson as Johnny Crackow

Tony Azito as Waiter

David Youse as Busboy

Louis Zorich as Mindy

Howard Brookner as Daffy Jack

John Rothman as Marvin Clay

Mark Nelson as Sam the Skate

Madeleine Potter as Widow Mary

Stellar Bennett as Thelma

Nicole Burdette as Woman on Corner

Colman deKay as Nosmo

Gerry Bamman as Inspector McNamara

Jane Brucker as Charlotte

Googy Gress as McGinty

Robert Donley as Doc Bodeeker

Grant Forsberg as Cab Driver

Sheldon Abend as Long George

Veryle Rupp as Whitey

Helmar Augustus Cooper as Brother Divine

George Ede as Judge Witherspoon

William S. Burroughs as Butler

Michael Wincott as Soupy Mike

Herschel Sparber as Big Shelley

Black-Eyed Susan as Minnie the Shrimp

Steve Buscemi as Whining Willie

Patrick Garner as Rodent Ralph

Tobin Wheeler as Fleming Meeks

Jean Brookner as Woman

Tamara Tunie as Cynthia Harris

Cathryn de Prume as Showgirl

Katherine Monick as Bobby Baker

Sara Driver as Yvette

William Murray Weiss as Joey the Toothpick

Leonard Termo as Goodtime Nate Fishkin

Graham Brown as Doc Frischer

Ed Zang as Hymie Weisberger

Linda Beausoleil as Showgirl

Cynthia Friberg as Showgirl

Lorien House as Showgirl

Dana Pinchera as Showgirl

Lynette Tompkins as Showgirl

Johnny Crawford as Musician