Casey Kasem as Shaggy (voice)

Jennifer Hale as Honey Hunsecker / Dr. Joan Goodfew (voice)

Mindy Cohn as Velma Dinkley (voice)

Grey DeLisle as Daphne (voice)

Frank Welker as Fred / Scooby-Doo (voice)

Bumper Robinson as Cap N' Robbie / Native Bearer (voice)

Kevin Michael Richardson as Lloyd Mbuku / Safari Member / Henry Hunsecker (voice)