Blythe Danner as Bee Bedloe

Edward Herrmann as Doug Bedloe

Melina Kanakaredes as Rita

Tom McCarthy as Ian Bedloe

Jeffrey Nordling as Danny Bedloe

Mary-Louise Parker as Lucy Dean Bedloe

Rene Augesen as Adult Agatha

Amy Hargreaves as Adult Daphne

Bethel Leslie as Mrs. Dulcimer

Glynnis O'Connor as Claudia Bedloe

Denis O'Hare as Reverend Emmett

Kristoffer Ryan Winters as Adult Thomas

Mary Lucy Bivins as Mrs. Jordan

Lori Rom as Cicely Brown

Hallee Hirsh as Young Agatha

Sam Gyllenhaal as Young Thomas

Julia McClernon as Young Daphne

Tracy Spindler as Agatha 12 Years

Joseph Cross as Thomas 10 Years

Heather Adams as Baby Daphne

Shannon Adams as Baby Daphne

Bill Raymond as B.B. Brandt

Molly Price as Clara

Pamela Gray as Dot

Ginnie Randall as Mrs. Myrdal

Erik Frey as Gideon (uncredited)

Dennis Gomez as Church Pianist (uncredited)

Michael Harding as Neighbor (uncredited)

Sang-Ho Lee as Medical Student (uncredited)

Lorri Lindberg as Churchwoman (uncredited)

Kawan Rojanatavorn as Steve (uncredited)

Wil Smith as Pedestrian (uncredited)