Kyle MacLachlan as Paul Atreides

Francesca Annis as Lady Jessica

Patrick Stewart as Gurney Halleck

Linda Hunt as Shadout Mapes

José Ferrer as Padisha Emperor Shaddam IV

Freddie Jones as Thufir Hawat

Brad Dourif as Piter De Vries

Richard Jordan as Duncan Idaho

Virginia Madsen as Princess Irulan

Silvana Mangano as Reverend Mother Ramallo

Everett McGill as Stilgar

Sting as Feyd Rautha

Kenneth McMillan as Baron Vladimir Harkonnen

Jack Nance as Nefud

Siân Phillips as Reverend Mother Gaius Helen Mohiam

Jürgen Prochnow as Duke Leto Atreides

Leonardo Cimino as The Baron's Doctor

Paul L. Smith as The Beast Rabban

Dean Stockwell as Doctor Wellington Yueh

Max von Sydow as Doctor Kynes

Alicia Witt as Alia

Sean Young as Chani

Danny Corkill as Orlop

Honorato Magaloni as Otheym

Judd Omen as Jamis

Molly Wryn as Harah

Angélica Aragón as Bene Gesserit Sister (uncredited)

Thomas Ebert as House Atreides Guard (uncredited)

Humberto Elizondo as Czigo (uncredited)

Ricardo Hill as (uncredited)

Ernesto Laguardia as Harkonnen's Victim (uncredited)

David Lynch as Spice Miner (uncredited)

Ramón Menéndez as Kinet (uncredited)

Ana Ofelia Murguía as Palace Maid (uncredited)

Claudia Ramírez as Fremen Girl (uncredited)

Julieta Rosen as Palace Maid (uncredited)

John Sabol as Fedaykin Fighter (uncredited)

Margarita Sanz as Lady Jessica's Maid (uncredited)

Jacqueline Voltaire as (uncredited)

José Luis García Mainou as (uncredited)