E. G. Daily as Tommy Pickles (voice)

Christine Cavanaugh as Chuckie Finster (voice)

Kath Soucie as Phil DeVille / Lil DeVille / Betty DeVille (voice)

Cree Summer as Susie Carmichael / Edwin Carmichael (voice)

Dionne Quan as Kimi Finster (voice)

Ron Glass as Randy Carmichael (voice)

Irma P. Hall as Aunt T. (voice)

Crystal Scales as Buster Carmichael (voice)

Hattie Winston as Lucy Carmichael / Lucy's Mom (voice)

Kimberly Brooks as Young Lucy (voice)

Bill Cobbs as Uncle Charles (voice)

Erv Immeman as Radio Announcer (voice)

Kevin Michael Richardson as Martin Luther King Jr. (voice)

Cynthia Kaye Hunt as Choir Soloist (voice)

Joe Alaskey as Grandpa Lou Pickles (voice)

Sam Saletta as Additional Voices (voice)

Bettina Bush as Alisa Carmichael (voice)