Paul Rudd as Pete

Leslie Mann as Debbie

John Lithgow as Oliver

Megan Fox as Desi

Maude Apatow as Sadie

Iris Apatow as Charlotte

Chris O'Dowd as Ronnie

Jason Segel as Jason

Melissa McCarthy as Catherine

Graham Parker as Graham Parker

Albert Brooks as Larry

Lena Dunham as Cat

Annie Mumolo as Barb

Robert Smigel as Barry

Charlyne Yi as Jodi

Lisa Darr as Clair

Billie Joe Armstrong as Billie Joe Armstrong

Michael Ian Black as Accountant

Wyatt Russell as Flirty Hockey Player

Tom Yi as Charlotte's Teacher

Tim Bagley as Dr. Pellegrino

Ava Sambora as Wendy

Megan Grano as School Playdate Parent

D.A. Sandoval as Older Pregnant Parent

Derek Basco as Room Service Waiter

Nicol Paone as E.R. Nurse

Lynne Alana Delaney as Disturbed Restaurant Patron (uncredited)

Katia Kieling as BBQ Guest (uncredited)

Bill Hader as Desi's Store Pickup (uncredited)

Tom Everett as Pete's Doctor

Tatum O'Neal as Realtor

Ryan Adams as Ryan Adams

Ryan Lee as Joseph

Dan Bakkedahl as Dentist

Jessica Lee as Party Guest #1 (uncredited)

Rebekka Johnson as Gyno Nurse

Johnny Pemberton as Room Service Waiter