Ben Stiller as Eddie Cantrow

Malin Åkerman as Lila

Michelle Monaghan as Miranda

Jerry Stiller as Doc

Rob Corddry as Mac

Mae LaBorde as Cute Elderly Couple Diner

Carlos Mencia as Tito

Scott Wilson as Boo

Polly Holliday as Beryl

Danny McBride as Martin

Roy Jenkins as Buzz

Stephanie Courtney as Gayla

Natalie Carter as 10 Year Old Girl

Nicol Paone as Esperanza Hotel Bar Patron

Miranda May as Tourist Daughter

Kathy Lamkin as Lila's Mom

Dean Norris as Jodi's Father

Leslie Easterbrook as Jodi's Mom

Eva Longoria as Consuela

Jackie Flynn as Beach Shack Customer

Gary Riotto as Wedding Coordinator

Mitch Rouse as Bicycle Mugger

Kayla Kleevage as Busty Woman in Hot Tub

Kenny Santiago Marrero as Wedding Dancer / Guest (uncredited)

Kevin J. Flynn as Flamboyant Man

Apple Farrelly as Kid At Wedding Table (as Apple Kocsis)

Amy Sloan as Deborah

Jerry Sherman as Grandpa Anderson

Lauren Bowles as Tammy