Josh Hartnett as Zeke Tyler

Elijah Wood as Casey Connor

Jordana Brewster as Delilah Profitt

Clea DuVall as Stokely 'Stokes' Mitchell

Shawn Hatosy as Stan Rosado

Laura Harris as Marybeth Louise Hutchinson

Salma Hayek Pinault as Nurse Rosa Harper

Famke Janssen as Miss Elizabeth Burke

Piper Laurie as Mrs. Karen Olson

Christopher McDonald as Mr. Frank Connor

Jon Stewart as Prof. Edward Furlong

Bebe Neuwirth as Principal Valerie Drake

Robert Patrick as Coach Joe Willis

Usher as Gabe Santora

Daniel von Bargen as Mr. John Tate

Summer Phoenix as F*** You Girl

Jon Abrahams as F*** You Boy

Danny Masterson as F*** Up #1

Wiley Wiggins as F*** Up #2

Susan Willis as Mrs. Jessica Brummel

Pete Janssen as Eddie 'Meat' McIvey

Tina Rodriguez as Tattoo Girl

Libby Villari as Casey's Mom

Harry Jay Knowles as Mr. Knowles

Donna Casey as Tina

Louis Black as Mr. Lewis

Eric Jungmann as Freshman #1

Chris Viteychuk as Freshman #2

Jim Johnston as P.E. Teacher

Duane Martin as Officer #1

Katherine Willis as Officer #2

Mike Lutz as Hornet Mascot

Douglas Aarniokoski as Brun Coach

Michelle Fairbanks as Student

Kidada Jones as Venus

Heath Young as Student / Football Fan (uncredited)

Michael Bliss as News Camera Man (uncredited)

R.C. Keene as Football Fan (uncredited)

Eric Vespe as Geek (uncredited)

Brad Schreiber as Hornet Football Player (uncredited)

Tony Tamayo as Football Game Attendee (uncredited)

Cassandra L. Small as School Office Clerk (uncredited)

Rick Olmos as Football Fan (uncredited)

Dannie Helen Loraine Knowles as Tatooed Pierced Girl #2 (uncredited)

Jason May as Biology Student (uncredited)