Eddie Murphy as Sherman Klump / Buddy Love / Lance Perkins / Papa Klump / Mama Klump / Grandma Klump / Ernie Klump

Jada Pinkett Smith as Carla Purty

James Coburn as Harlan Hartley

Larry Miller as Dean Richmond

Dave Chappelle as Reggie Warrington

John Ales as Jason

Patricia Wilson as Dean's Secretary

Jamal Mixon as Ernie Klump, Jr.

Nichole McAuley as Fit Woman

Hamilton von Watts as Health Instructor

Chao-Li Chi as Asian Man

Tony Carlin as Host

Quinn Duffy as Bartender

Montell Jordan as Montell Jordan

Doug Williams as Band Leader

David Ramsey as Student

Chaz Lamar Shepherd as Student

Lisa Halpern as Sad Fat Firl

Mark McPherson as Doctor

John Prosky as Doctor

Michael Rothhaar as Doctor

Sara Ballantine as Nurse

Greg Natale as Cop

Roy Werner as Guy in Crowd

Retha Jones as Woman in Crowd

Steve Monroe as Student

Joe Greco as Security Guard

Nick Kokotakis as Waiter

Stanley D. Petter III as Fireman

Mohamed Mohsen as Bodybuilder

Michael D. Starks as Boxing Trainer

Julianne Christie as Sporting Goods Clerk

Christie Blanchard-Power as Woman Dignitary

Alexia Robinson as Sexy Girl

Lisa Boyle as Sexy Girl

Athena Massey as Sexy Girl

Judith Woodbury as Wellman College Alumni

Arthur Tovey as Elderly Man in Alumni Receiving Line (uncredited)

Ned Luke as Construction Worker (uncredited)