Tyler Perry as Dr. Alex Cross

Edward Burns as Tommy Kane

Matthew Fox as Picasso

Rachel Nichols as Monica Ashe

Carmen Ejogo as Maria Cross

Jean Reno as Gilles Mercier

John C. McGinley as Richard Brookwell

Giancarlo Esposito as Daramus Holiday

Cicely Tyson as Nana Mama

Chad Lindberg as Vincent Dardis

Stephanie Jacobsen as Fan Yau

Sonny Surowiec as Hans Friedlich

Yara Shahidi as Janelle Cross

Gary A. Jones as Funeral Guest (uncredited)

Simon Rhee as Fan Yau Bodyguard #3

Alexandra Ruddy as Brookwell Aide

Christian 'Trick Trick' Mathis as Fight Manager

Werner Daehn as Erich Nunemacher

Sayeed Shahidi as Damon Cross

Bonnie Bentley as Detective Jody Klebanoff

Keith Cameron as Bodyguard

Simenona Martinez as Pop Pop Jones

Jessalyn Wanlim as Paramita Megawati

Tim Holmes as Referee

Ingo Rademacher as Ingo Sacks

Tiren Jhames as Guard Manning Station

Darcy Leutzinger as Bomb Squad Head

Peter Lawson Jones as Minister

Christopher Stadulis as Soon to Be Dead Man #1

Timothy J. Richardson as Soon to Be Dead Man #2

Steffen Dziczek as Soon to Be Dead Man #3

Ideene Dehdashti as Screaming Girl

Dave Bender as Lieutenant Max

Marcelo Tubert as Cloche

Rory Markham as Nenad Stanisic

Ray Goodwin as Fan Yau Bodyguard #1

Danny Wynands as Fan Yau Bodyguard #2

Andrew Comrie-Picard as Mercier's Driver

Tim Sitarz as Packard Plant Rapist

Anthony Akins as Patron in Restaurant (uncredited)

Nikky Smedley as MMA Fight Fan (uncredited)

Mel Chude as K-Rash (uncredited)

Ron Causey as MMA Fight Fan (uncredited)

Jennifer James Davies as Police Detective (uncredited)

Dominic Ryan Gabriel as MMA Fight Fan (uncredited)

Aswan Harris as Detective (uncredited)

Sherry Hudak as Psychiatrist (uncredited)

Robert Graziosi as Attorney in Courthouse (uncredited)

Bridget Ogundipe as Principal (uncredited)

Rance Martin as Detective (uncredited)

John Newkirk as Forensic Photographer (uncredited)

Janine Sarnowski as Pedestrian Extra (uncredited)

Benny Tjandra as Indonesian Driver / Soldier (uncredited)

Brent Reichert as Police Officer (uncredited)

Takesha L. Walker as Screaming Woman (uncredited)