Colin Farrell as Alexander

Angelina Jolie as Olympias

Val Kilmer as Philip

Jared Leto as Hephaistion

Jonathan Rhys Meyers as Cassander

Anthony Hopkins as Old Ptolemy

Jessie Kamm as Young Alexander

Christopher Plummer as Aristotle

Connor Paolo as Young Alexander

Patrick Carroll as Young Hephaistion

Peter Williamson as Young Nearchus

Morgan Christopher Ferris as Young Cassander

Rob Earley as Young Ptolemy

Aleczander Gordon as Young Perdiccas

John Kavanagh as Parmenion

Gary Stretch as Cleitus

Rosario Dawson as Roxane

Toby Kebbell as Pausanius

Fiona O'Shaughnessy as Nurse

Laird Macintosh as Greek Officer

Francisco Bosch as Bagoas

Neil Jackson as Perdiccas

Rory McCann as Crateros

Raz Degan as Darius III

Joseph Morgan as Philotas

David Bedella as Scribe

Brian Blessed as Wrestling Trainer

Nick Dunning as Attalus

Elliot Cowan as Ptolemy

Ian Beattie as Antigonus

Denis Conway as Nearchus

Michael Dixon as Campfire Soldier

Tim Pigott-Smith as Omen Reader

Erol Sander as Persian Prince

Stéphane Ferrara as Bactrian Commander

Tadhg Murphy as Dying Soldier

Annelise Hesme as Stateira

Marie Meyer as Eurydice

Mick Lally as Horse Seller

Garrett Lombard as Leonnatus

Chris Aberdein as Polyperchon

Jean Le Duc as Fat Eunuch

Mohammed Tsouli as Persian Chamberlain

Rab Affleck as Attalus' Henchman

Féodor Atkine as Roxane's Father

Harry Kent as Cup Bearer #1

Sam Green as Cup Bearer #2

Bin Bunluerit as Indian King

Jaran Ngamdee as Indian Prince

Brian McGrath as Doctor

Suzanne Bullock as Roxane Dancer

Kate Eloise Whitfield as Roxane Dancer

Gillian Grueber as Roxane Dancer

Michelle Lukes as Roxane Dancer

Anjali Mehra as Roxane Dancer

Anthony Jean Marie Kurt as Bagoas Dancer

Marta Barahona as Bagoas Dancer

Monica Zamora as Bagoas Dancer

Benny Maslov as Bagoas Dancer

Tania Matos as Bagoas Dancer

Leighton Morrison as Bagoas Dancer

Isaac Mullins as Bagoas Dancer

Monica Perego as Bagoas Dancer

Matthew Powell as Bagoas Dancer

Benjamín Benítez as Amato (uncredited)

Anthony James Berowne as Greek Courtier (uncredited)

Nicolas D. Blake as Palace Page (uncredited)

Max Bollinger as Young Greek Official (uncredited)

Jason Croot as Peasant (uncredited)

Dale Dye as Macedonian Veteran at Hyphasis Speech (uncredited)

Fahar Faizaan as Alexander - Voiceover (uncredited)

Charles Haigh as Aristander (uncredited)

Abbie Hirst as Octavia (uncredited)

Charlie Hollway as Boy (uncredited)

Rowley Irlam as Pausanius's Accomplice (uncredited)

David Leon as Hermolaous (uncredited)

Evelina Manna as Apparition (uncredited)

Desmond O'Neill as Acolyte at Sacrifice (uncredited)

Greg Orvis as Celtic Diplomat (uncredited)

Panayiota Panteli as Indian Servant (uncredited)

Lee Anthony Parnell as Warrior (uncredited)

John Reynolds as Dexapous (uncredited)

Peter Rnic as Greek Nobleman (uncredited)

Oliver Stone as Macedonian Soldier at Zeus Statue (uncredited)