Alexa PenaVega as Carmen Cortez

Daryl Sabara as Juni Cortez

Antonio Banderas as Gregorio Cortez

Carla Gugino as Ingrid Cortez

Steve Buscemi as Romero

Mike Judge as Donnagon

Danny Trejo as Machete

Cheech Marin as Felix Gumm

Matt O'Leary as Gary Giggles

Emily Osment as Gerti Giggles

Ricardo Montalban as Grandfather

Holland Taylor as Grandmother

Alan Cumming as Fegan Floop

Tony Shalhoub as Alexander Minion

Taylor Momsen as President's Daughter

Christopher McDonald as President of the USA

Bill Paxton as Dinky Winks

Dale Dudley as Head Magna Man

Troy Robinson as Magna Man / Waiter

Ron Hayden as Main Secret Agent

Brian Thornton as Secret Agent #2

Mark Turner as Secret Agent #3

Jasmine Marin as Spy Girl

Angela Lanza as Park Public Relations

Felix Sabates as Test Family

Lynda Sabates as Test Family

Alexandra Sabates as Test Family

Victoria Sabates as Test Family