Michael J. Fox as Stuart Little (voice)

Geena Davis as Mrs. Little

Hugh Laurie as Mr. Little

Jonathan Lipnicki as George Little

Anna Hoelck as Martha Little

Ashley Hoelck as Martha Little

Nathan Lane as Snowbell (voice)

Melanie Griffith as Margalo (voice)

James Woods as Falcon (voice)

Steve Zahn as Monty (voice)

Marc John Jefferies as Will

Angelo Massagli as Wallace

Jim Doughan as Soccerball Coach

Brad Garrett as Plumber

Conan McCarty as Referee

Maria Bamford as Teacher

Daniel Hansen as Student

Kevin Olson as Irwin

Dyllan Christopher as Kid

Bobby Walsh as Tony

Michael C. Fuchs as Mark

Raymond Ma as Chef

Amelia Marshall as Will’s Mom

Ronobir Lahiri as Cab Driver

Connie Roderick as Nun

David Tabatsky as Balloon Man

Frank Aquilino as Onlooker

Salvatore Pate as Onlooker

Rachael Harris as Additional Voices (voice)