Tom Cruise as Ethan Hunt

Philip Seymour Hoffman as Owen Davian

Ving Rhames as Luther

Billy Crudup as Musgrave

Michelle Monaghan as Julia

Jonathan Rhys Meyers as Declan

Keri Russell as Lindsey Farris

Maggie Q as Zhen

Simon Pegg as Benji

Eddie Marsan as Brownway

Laurence Fishburne as Theodore Brassel

Bahar Soomekh as Davian's Translator

Jeff Chase as Davian's Bodyguard

Michael Berry Jr. as Julia's Kidnapper

Carla Gallo as Beth

Bellamy Young as Rachael

Paul Keeley as Ken

Jane Daly as Julia's Mother

Greg Grunberg as Kevin

Sabra Williams as Annie

Rose Rollins as Ellie

Sasha Alexander as Melissa

Tracy Middendorf as Ashley

Aaron Paul as Rick

Kathryn Fiore as Party Goer

Colleen Crozier as Party Goer

Sean O'Bryan as Party Goer

Bruce French as Minister

Ellen Bry as Lindsey's Mother

Patrick Pankhurst as Lindsey's Father

Tony Guma as Jim

James Shanklin as Hospital Chaplain

Anne Betancourt as Nurse Sally

Antonietta De Lorenzo as Roadblock Driver

Andrea Sartoretti as Roadblock Driver

Antonio Del Prete as Vatican Video Room Guard

Francesco De Vito as Greeting Priest

Giorgio Marchesi as Vatican Gate Guard

Niccolò Senni as Vatican Gate Guard

Paolo Bonacelli as Monsignore

David Waters as IMF Officer

Michael G. Kehoe as Hospital Employee

Timothy Omundson as IMF Agent

José Zúñiga as IMF Agent Pete

William Francis McGuire as IMF Head of Security

Michelle Arthur as Airline Worker

Barney Cheng as Janitor

George Cheung as Shanghai Game Player (uncredited)

Brandon Molale as Torturer (uncredited)

Simon Rhee as Chinese Guard at Hengshan Lu Building (uncredited)

Marcus Young as Chinese Guard (uncredited)

Jerry Trimble as Davian's Thug (uncredited)

Alex Kurtzman as Party Guest (uncredited)

Roberto Orci as Party Guest (uncredited)