Matt Lucas as Franklin Franklin

Juno Temple as Simone

James Caan as Mr. Allspice

Dolph Lundgren as Dr. Sage Mennox

Billy Crystal as Burt Walnut

Peter Stormare as Dr. Olivetti

DJ Qualls as Artie

Johnny Knoxville as Tommy Balls

Rebel Wilson as Rocky

Rosie Perez as Ms. Baker

Tara Holt as Amber

James Marsden as Bernard Franklin

Saffron Burrows as Francine

David Koechner as Detective O'Grady

Noel Gugliemi as Dog Walker

Ned Bellamy as EMT / Daniel

Scott Sheldon as Officer Smith

David Warshofsky as Detective Holman

Dennis L.A. White as Marcus

Alex Solowitz as Sebastian

Amanda Plummer as Mrs. Ballisteri

Jennifer Echols as Psych Center Receptionist

Soraya Andrade as Bookstore Girl

Angela Lindvall as Flight Attendant / Lisa

Jacqueline Cereceres as Swiss Miss

Natalie Cohen as Swiss Miss

Chanel Ryan as Swiss Miss