Tim Allen as Dave Douglas

Kristin Davis as Rebecca Douglas

Danny Glover as Ken Hollister

Spencer Breslin as Josh Douglas

Robert Downey Jr. as Dr. Kozak

Zena Grey as Carly Douglas

Joshua Leonard as Justin Forrester

Jane Curtin as Judge Claire Whittaker

Annabelle Gurwitch as Justin Forrester's Attorney

Jarrad Paul as Larry

Bess Wohl as Dr. Gwen Lichtman

Philip Baker Hall as Lance Strictland

Shawn Pyfrom as Trey

Joel David Moore as Pound Employee

Kevin Cooney as Doctor

Craig Kilborn as Baxter

Jeanette Brox as Janey

Rhea Seehorn as Lori

Koji Kataoka as Monk

Casey Sander as Leader

Mark Robert Ellis as Football Coach

Jesse Heiman as Pound Employee (uncredited)

Mic Rodgers as Bus Driver

Eric Winzenried as Animal Control Officer

Adam Hicks as Quarterback

Michael Tyler Henry as Obnoxious Player #1

Chris Weaver as Protest Leader

Crystal the Monkey as Capuchin (uncredited)

Linda Griffin as Additional Voice (voice) (uncredited)