Molly Shannon as Mrs. Baker

Liam Aiken as Owen Baker

Matthew Broderick as Hubble (voice)

Donald Faison as Wilson (voice)

Cheech Marin as The Greater Dane's Henchman (voice)

Brittany Murphy as Nelly (voice)

Vanessa Redgrave as The Greater Dane (voice)

Carl Reiner as Shep (voice)

Delta Burke as Barbara Ann (voice)

Kevin Nealon as Mr. Baker

Hunter Elliott as Frankie

Mikhael Speidel as Fred

Brittany Moldowan as Connie Fleming

George Touliatos as Mr. Leone

Patti Allan as Ms. Ryan

Ben Immanuel as Wilson's Dad (as Benjamin Ratner)

Peter Flemming as Wilson's Other Dad

Paul Vogt as Bob the Dog Catcher (as Paul C. Vogt)

Brenda Crichlow as Mrs. Fleming (as Brenda M. Crichlow)

D. Harlan Cutshall as Mr. Fleming

Chaka White as Woman at the Pound

Nicola Anderson as Woman at the Pound

Ted Friend as TV Anchorman

Susan Bain as House Bidder

Banner as Barbara Ann

Willie as Shep

Mig Macario as Asian Dad (uncredited)