Michael Keaton as Andy

Mila Kunis as Grace

Carmen Ejogo as Lola

Michael Urie as Terry

Kevin Pollak as Cy

Vivien Lyra Blair as Billie

Nico Hiraga as Jonny

Jacob Kopera as Mose

Danny Deferrari as Pete

Poorna Jagannathan as Dr. Verma

Andrew Leeds as Greg

Laura Benanti as Naomi

Andie MacDowell as Ann

Kimberly Condict as Cecile

Noa Fisher as Tali

Jessica Heller as Becca

Monique Moses as Teacher

Carlos Solórzano as Alexander

Chloe Troast as Chloe

Liza Treyger as Comedian

Lois Shih as Neighbor

Carlos Ragas as Bald Man

Sydney Miles as Iris

Miles Anderson as Barry Klein

Michael Chieffo as Ed

Roshni Shukla as Sandy

Crosby Fitzgerald as Annie

Chander Daya as Artist (uncredited)

Michelle Marie Jacquot as Artist (uncredited)

Dominique Star as Drummer (uncredited)

Shannon Bengston as Goth Clerk (uncredited)

Maggie Vlasaty as Saxophonist (uncredited)

Maria Bata as Woman in the Bar (uncredited)

Gracie Cartier as (uncredited)

Susan Thomas Walker as Ed's Friend at Party (uncredited)

Ana Gonzalez as Gallery Employee (uncredited)

Shey Bogumil as Hospital Pedestrian (uncredited)