David Spade as Kuzco (voice)

John Goodman as Pacha (voice)

Eartha Kitt as Yzma (voice)

Patrick Warburton as Kronk (voice)

Wendie Malick as Chicha (voice)

Kellyann Kelso as Chaca (voice)

Eli Russell Linnetz as Tipo (voice)

Stephen J. Anderson as Additional Voices (voice)

Bob Bergen as Additional Voices (voice)

Rodger Bumpass as Additional Voices (voice)

Robert Clotworthy as Additional Voices (voice)

Jennifer Darling as Additional Voices (voice)

Patti Deutsch as Additional Voices (voice)

John Fiedler as Additional Voices (voice)

Miriam Flynn as Additional Voices (voice)

Geri Lee Gorowski as Additional Voices (voice)

Sherry Lynn as Additional Voices (voice)

Danny Mann as Additional Voices (voice)

Mickie McGowan as Additional Voices (voice)

D.F. Reynolds as Additional Voices (voice)

Andre Stojka as Additional Voices (voice)

Steve Susskind as Additional Voices (voice)

Joe Whyte as Additional Voices (voice)

Jack Angel as Villagers (voice) (uncredited)

Mark Dindal as Kitty Yzma (voice) (uncredited)

Bill Farmer as Villagers (voice) (uncredited)

Carole Jeghers as Jaguars (voice) (uncredited)

Tom Jones as Theme Song Guy (voice) (uncredited)

Patrick Pinney as Villagers (voice) (uncredited)

Jess Harnell as Additional Voices (voice)

Phil Proctor as Villagers (voice) (uncredited)