John Travolta as Bolt (voice)

Susie Essman as Mittens (voice)

Mark Walton as Rhino (voice)

Malcolm McDowell as Dr. Calico (voice)

Miley Cyrus as Penny (voice)

James Lipton as The Director (voice)

Greg Germann as The Agent (voice)

Diedrich Bader as Veteran Cat (voice)

Nick Swardson as Blake (voice)

J.P. Manoux as Tom (voice)

Dan Fogelman as Billy (voice)

Kari Wahlgren as Mindy Parker (voice)

Chloë Grace Moretz as Young Penny (voice)

Randy Poffo as Thug (voice)

Ronn Moss as Dr. Forrester (voice)

Grey DeLisle as Penny's Mom (voice)

Sean Donnellan as Penny's TV Dad (voice)

Lino DiSalvo as Vinnie (voice)

Todd Cummings as Joey (voice)

Tim Mertens as Bobby (voice)

Kelly Hoover as Ester (voice)

Brian Stepanek as Martin (voice)

Jeff Bennett as Lloyd (voice)

Daran Norris as Louie (voice)

John DiMaggio as Saul (voice)

Jenny Lewis as Assistant Director (voice)

Anne Lockhart as Additional Voices (voice)

Phil LaMarr as Additional Voices (voice)

June Christopher as Additional Voices (voice)

Christin Ciaccio Briggs as Additional Voices (voice)

David Cowgill as Additional Voices (voice)

Terri Douglas as Additional Voices (voice)

Jackie Gonneau as Additional Voices (voice)

Nathan Greno as Additional Voices (voice)

Forrest Iwaszewski as Additional Voices (voice)

Holly Kaneko as Additional Voices (voice)

Daniel Kaz as Additional Voices (voice)

Dara McGarry as Additional Voices (voice)

Scott Menville as Additional Voices (voice)

Jonathan Nichols-Navarro as Additional Voices (voice)

Paul Pape as Additional Voices (voice)

Lynwood Robinson as Additional Voices (voice)

Karen Ryan as Additional Voices (voice)

Tara Strong as Additional Voices (voice)

Pepper Sweeney as Additional Voices (voice)

Joe Whyte as Additional Voices (voice)

Chris Williams as Additional Voices (voice)

Stephen J. Anderson as Additional Voices (voice)