Drake Bell as Rick Riker / Dragonfly

Sara Paxton as Jill Johnson

Christopher McDonald as Lou Landers

Leslie Nielsen as Uncle Albert Adams

Kevin Hart as Trey

Marion Ross as Aunt Lucille

Ryan Hansen as Lance Landers

Keith David as The Chief of Police

Brent Spiner as Dr. Strom

Robert Joy as Dr. Hawking

Jeffrey Tambor as Dr. Whitby

Robert Hays as Blaine Riker

Nicole Sullivan as Julia Riker

Sam Cohen as Young Rick

Regina Hall as Mrs. Xavier

Marisa Lauren as Storm

Craig Bierko as Wolverine (scenes deleted)

Richard Tillman as Leg-Shaving Wolverine

Simon Rex as The Human Torch

Dan Castellaneta as Carlson

Atom Gorelick as Stretchy Boy

Alison Woods as Stretchy Girl

Eric Artell as Sneezo

Sean Simms as Barry Bonds

Pamela Anderson as Invisible Girl

Miles Fisher as Tom Cruise

Brian Carpenter as Matthews

Vincent Larusso as Bank Robber

Michael Papajohn as "Gimme your wallet"

Anna Osceola as "Dr. Hawking, I am such a fan"

Rod McLachlan as Actual Editor

John Getz as Lunatic Editor

Charlene Tilton as Jill's Mother

Jenica Bergere as "Mr. Landers!"

Byrne Offutt as Reporter Ed

Vic Polizos as Undertaker

Daryl J. Johnson as "Well, an old guy did get shot over there"

Kent Shocknek as News Anchor

Amanda Carlin as Principal

Clay Greenbush as Dead Blonde Woman's Husband

Kurt Fuller as Bank Loan Officer

Seth McCook as Paperclip Guy

Craig Mazin as "Okay, I come back"

Jonathan Chase as Onlooker #1

Kourtney Kaas as Onlooker #2

Karlton Johnson as Truck Driver

Charles W. Gray as "Thanks for the loan, Mr. Thompson"

Wendy L. Walsh as Live Reporter

Ian Patrick Williams as King of Sweden

Elisabeth Noone as "Take me...."

Aki Aleong as Dalai Lama

Howard Mungo as Nelson Mandela

David McKnight as Bishop Tutu

Freddie Pierce as Tony Bennett

Steve Monroe as Nerdy Dragonfly

Jerry Haleva as Saddam Hussein

Jeremiah Hu as Asian Hourglass

Matt Champagne as "Excuse me, there's a line!"

Susan Breslau as Mourner

Nick Kiriazis as Police Officer

Aubrie Lemon as Dead Blonde Woman

Ajay Mehta as Convenience Store Owner

Cameron Ali Sims as Xavier's Son

Lil' Kim as Xavier's Daughter

Jordan Rubin as The Guy Who Wipes Wolverine's Ass (scenes deleted)

Shanna Beauchamp as Student (uncredited)

James J. Burke as YouTube User (uncredited)

Kristen Endow as HS Student (uncredited)

Timothy Farmer as Kid in the Orange Beanie (uncredited)

Whitney Ann Jenkins as Pink Superhero (uncredited)

James Lew as Shaolin Monk (uncredited)

Alan Mueting as Security Man (uncredited)

Gene Richards as Chicken Man (uncredited)

Marque Richardson as Xavier's Older Son (uncredited)

Thomas Rosales Jr. as Bandit in Alley (uncredited)

Jeffry Tamara as Student (uncredited)

Manu Toigo as Award Presenter (uncredited)

Julie Van as Neo-Batgirl (uncredited)

Tracy Morgan as Professor Xavier

Robert Bezanilla as EMT (uncredited)