Bruce Willis as Dwayne Hoover

Albert Finney as Kilgore Trout

Nick Nolte as Harry Le Sabre

Barbara Hershey as Celia Hoover

Glenne Headly as Francine Pefko

Lukas Haas as George 'Bunny' Hoover

Omar Epps as Wayne Hoobler

Vicki Lewis as Grace Le Sabre

Buck Henry as Fred T. Barry

Ken Hudson Campbell as Eliot Rosewater / Gilbert

Jake Johannsen as Bill Bailey

Will Patton as Moe The Truck Driver

Chip Zien as Andy Wojeckowzski

Owen Wilson as Monte Rapid

Alison Eastwood as Maria Maritimo

Shawnee Smith as Bonnie MacMahon

Michael Jai White as Howell

Keith Joe Dick as Vernon Garr

Diane Willson Dick as Rosemary Garr

Michael Clarke Duncan as Eli

Lahmard J. Tate as Elmoro

Kurt Vonnegut as Commercial Director

Dawn Didawick as Lottie

Karl Wiedergott as Homer

Patti Allison as Blossom

Alexa Robbins as Art Hostess Kaye

Debra Dusay as Art Hostess Faye

Tom Robbins as Pesky Weber

Raymond O'Connor as Rabo Karabekian

Tisha Sterling as Beatrice Keedsler

Matt Callahan as Zeke

Tracey Lee Mapstone as Mailwoman

Mary Kennedy as Waitress

Greg Walker as Highway Patrolman

David Blampied as NY Policeman / Prison Guard

Greg Moore as Porn Store Patron

Doug Hamblin as Mugger

Thomas Patrice as NY Policewoman

Nancy Volle as Marlo

Danielle Kennedy as Motel Clerk

Scout LaRue Willis as Young Girl

Nicolas Small as Young Boy

Denise Simone as Blue Monday Housewife

Russ Wilson as Blue Monday Doctor

Scott Beauchemin as Trypepton Husband

Kassandra Kay as Trypepton Wife

Ken Odom as Prodigal Life Husband

Erica Evans as Prodigal Life Wife

David Kyle as Prodigal Life Child

Richard Sheehan as Voiceover

Roman Lewis as Prisoner

Gina-Raye Carter as Woman Inside of Bruce Willis' Brain (uncredited)

Maxann Crotts as Serial Killer (uncredited)

William L. Nagle as Horace Durenwurst (uncredited)

Beaux Sedwick as Dream Girl (uncredited)