Jerry Seinfeld as Barry B. Benson (voice)

Renée Zellweger as Vanessa Bloome (voice)

Matthew Broderick as Adam Flayman (voice)

Patrick Warburton as Ken (voice)

John Goodman as Layton T. Montgomery (voice)

Chris Rock as Mooseblood (voice)

Kathy Bates as Janet Benson (voice)

Barry Levinson as Martin Benson (voice)

Larry King as Bee Larry King (voice)

Ray Liotta as Ray Liotta (voice)

Sting as Sting (voice)

Oprah Winfrey as Judge Bumbleton (voice)

Larry Miller as Buzzwell (voice)

Megan Mullally as Trudy (voice)

Rip Torn as Lou Lo Duca (voice)

Michael Richards as Bud Ditchwater (voice)

Mario Joyner as Jackson (voice)

Jim Cummings as Narrator / Graduation Announcer (voice)

Tom Papa as Splitz / Klauss Vanderhayden (voice)

Andy Robin as Jock #2 (voice)

David Pimentel as Hector (voice)

Chuck Martin as Andy (voice)

Conrad Vernon as Freddy (voice)

David Herman as Buzz / Bob Bumble / Pilot (voice)

Carol Leifer as Press Person #1 (voice)

Jeff Altman as Uncle Carl (voice)

Brian Hopkins as Sandy Shrimpkin / TSA Agent (voice)

Tress MacNeille as Jeanette Chung / Mother / Cow (voice)

Nathan D. Morrissey as Boy Crying / Timmy (voice)

Olivia Mattingly as Little Girl (voice)

Simon J. Smith as Truck Driver / Chet (voice)

Geoff Witcher as Press Person #2 / Jock #1 (voice)

John DiMaggio as Janitor / Bailiff (voice)

Barry Marder as Waterbug (voice)

Sean Bishop as Ladybug (voice)