Colin Farrell as Jesse James

Scott Caan as Cole Younger

Ali Larter as Zerelda "Zee" Mimms

Gabriel Macht as Frank James

Gregory Smith as Jim Younger

Harris Yulin as Thaddeus Rains

Kathy Bates as Ma James

Timothy Dalton as Allan Pinkerton

Will McCormack as Bob Younger

Ronny Cox as Doc Mimms

Terry O'Quinn as Rollin H. Parker

Nathaniel Arcand as Comanche Tom

Ty O'Neal as Clell Miller

Joe Stevens as Loni Packwood

Barry Tubb as Captain Malcolm

Jack Watkins as Detective

Tom Schuster as Union Officer

Lee Ritchey as Bank Manager

Robin Christian-McNair as Woman

Ed Geldart as Old Man Tucker

Brad Leland as Sheriff

Craig Erickson as Deputy

Mark Walters as Engineer

Michael Stephen Costello as Senator

Jack Gould as Head Teller

Morgana Shaw as Lyla

Brady Coleman as Driver

Richard Andrew Jones as Pastor

Steven Bland as Man

Jerry Cotton as Teller

Muse Watson as Burly Detective

Lane Thomas Wilson as Boy Soldier

Ron Hayden as Union Lieutenant

Darryl Cox as Jenkins

Riley Flynn as Union Commander

Joe Brown as Pinkerton Commander

Shawn Patrick Nash as Hangman

Jessica M.E. Nitsch as Loni's Girl

Big Skinny Brown as Harlan (uncredited)

Pei-San Brown as Saloon Girl (uncredited)

Anne Carr as Gang Horse Rider (uncredited)

Steve Crawford as Troublemaker (uncredited)

Frank G. Curcio as Hold-up Victim (uncredited)

Lisa Del Dotto as Townsfolk (uncredited)

Jeremy Denzlinger as Hyperion Townsfolk (uncredited)

Troy Dillinger as Pinkerton / Sniper (uncredited)

Kirk Hunter as Townsfolk (uncredited)

David Jachin Kelley as Sharpshooter (uncredited)

Marvin Schroeder as Pinkerton Man (uncredited)

Chris Warner as Railroad Worker (uncredited)

Gena West as Townsfolk (uncredited)

Paul Wright as Civil War Veteran (uncredited)