William Powell as Nick Charles

Myrna Loy as Nora Charles

James Stewart as David Graham

Elissa Landi as Selma Forrest Landis

Joseph Calleia as 'Dancer'

Jessie Ralph as Aunt Katherine Forrest

Alan Marshal as Robert Landis

Teddy Hart as Floyd Casper

Sam Levene as Lt. Abrams

Penny Singleton as Polly Byrnes

William Law as Lum Kee

George Zucco as Dr. Adolph Kammer

Paul Fix as Phil Byrnes / Ralph West

Skippy as Asta

Ward Bond as Party Guest (uncredited)

Donald Briggs as Reporter (uncredited)

Mary Gordon as Rose (uncredited)

Allen 'Farina' Hoskins as Screwy (uncredited)

Hal Le Sueur as Polly's Admirer (uncredited)

Roger Moore as Reporter (uncredited)

Tom Ricketts as Henry the Butler (uncredited)

Constantine Romanoff as Wrestler at Party (uncredited)

Zeffie Tilbury as Aunt Lucy (uncredited)

Sue Moore as Sexy Blonde (uncredited)

Lucille Ward as Prison Matron (uncredited)

Harry Tyler as Fingers (uncredited)

Murray Alper as The Kid (uncredited)

John Kelly as Harold the Chauffer (uncredited)

William Benedict as Newsboy (uncredited)

James Carlisle as Man Reading Newspaper (uncredited)

Charles Fogel as Nightclub Patron (uncredited)

Joe Phillips as Willie the Weeper (uncredited)

Charles Trowbridge as Ballistics Man (uncredited)

Fred Santley as Reporter (uncredited)

Dick Rush as San Francisco Detective (uncredited)

Lee Phelps as Flop House Proprietor (uncredited)

Barbara Pepper as Party Guest (uncredited)

Harvey Parry as Man Standing on Hands (uncredited)

Carl M. Leviness as Nightclub Patron (uncredited)

Fred Graham as Newspaper Distributor (uncredited)

Edgar Dearing as Bill (uncredited)

Heinie Conklin as Trainman (uncredited)

Ralph Brooks as Nightclub Patron (uncredited)

Phil Bloom as Nightclub Patron (uncredited)

Margaret Bert as Nightclub Customer During Polly's Singing Act (uncredited)

Vince Barnett as Wrester's Manager (uncredited)

Charles Arnt as Drunk (uncredited)