David Cross as Ronnie Dobbs / Pootie T / Chow Chow

Bob Odenkirk as Terry Twillstein / Wolfgang Amadeus Thelonius Von Funkenmeister the XIX 3 / 4 / Daffy Mal Yinkle Yankle

Bruce Taylor as Dot Lancaster

Leon Lamar as Tammy's Neighbor

India Cosper as Middle Ronnie

Blaze Walker as Little Middle Ronnie

Storm Walker as Little Ronnie

Jill Talley as Tammy

Paul Carden as Tas-Tee Liquor Store Owner

Becky Thyre as Tonya

Suli McCullough as Kyle

David Koechner as Clay

Saucy as F'd Up Dog

E.J. De la Pena as Jerry Trellis

Jonathon Pelletier as 9 Year Old Ronnie

Kimberly Schwartz as 9 Year Old Tammy

Matthew Draper as 12 Year Old Ronnie

Amber Brooke as 12 Year Old Tammy

M.C. Gainey as Hark Trellis

Frank Hoyt Taylor as Frank - 'Fuzz' Cop

Bill Rowell as Bill - 'Fuzz' Cop

Pearlyne Irving as Darnetta

Shawn Maurer as 'Fuzz' Cameraman

Tommy Smeltzer as Police Station Guard

Brett Paesel as Infomercial Nancy

Brian Posehn as Tank

Patton Oswalt as Dozer - Editor #1

Donna Wright as Undercover Hooker

Ken Daly as Editor #2

Doug Benson as Editor #3

Dean Holland as Editor #4

John Matta as Editor #5

Blaine Cartwright as Duke's Bar Owner

Ted Manson as Oldie Bowling Alley Man

Kenny Alfonso as High School Cop

Greg Behrendt as Radio DJ 'The Lemur'

Dave Foley as Network Executive #1

Andy Richter as Network Executive #2

Sarah Silverman as Network Executive #3

Trey Parker as Self

Matt Stone as Self

Rebecca Romijn as Self

John Stamos as Self

Colin Malone as Self

Garry Shandling as Self

Scott Ian as Self

Kathy Griffin as Self

Craig Anton as Holywood Agent

Laura Kightlinger as Birthday Woman

Jeff Garlin as Birthday Woman's Friend

Christopher Nguyen as Chow Chow

John Andrews as Party Photographer

Drew McWeeny as Self

Scott Thompson as Self

Patrick Warburton as Head of Gay Conspiracy

Nikki Cox as Kayla

Elisha Choice as Music Video

Tom Kenny as TV News Reporter / Cult Leader Gleh'n

Paul F. Tompkins as Safari Guy in TV

Wendy Cross as Terry's NYC Assistant

Mandy Patinkin as Self

Cookie Brindle as Terry's NYC Assistant #1

Mary Lynn Rajskub as Self

Jim Turner as Self

Jack Black as Lead Chimney Sweep

Scott Adsit as Police Negotiator

R. Lee Ermey as Lead Kidnapper

Scott Aukerman as Starving Kidnapper

Lance Bangs as Gay Conspiracy Technician

Jeff Goldblum as Self

Maynard James Keenan as Titannica Lead Singer

Jim Norton as Cop

Kulap Vilaysack as Gay Female Military Type #2

Morwenna Banks as British Couple

Zia Harris as Cult Member Gr'hg

Ben Stiller as Self

Bill Crabb as Prison Guard