Saffron Burrows as Melody

Isaach de Bankolé as Roscoe Wasz

Paz de la Huerta as Cookie

Adam Trese as Mr. Laffs

Janeane Garofalo as Dr. Murray

Reg Rogers as Brett

Elizabeth Marvel as Ma Wilder

David Wain as Phone Man

Bill Camp as Pa Wilder

Richard Short as Loser Musician

Mia Kucan as Melody - Young

Lawrence Ballard as Doctor

Ashlie Atkinson as Receptionist

Larry Block as Mr. Faddis

Lori Tan Chinn as Mrs. Tzu

William Leroy as Billy

Virginia Wing as Ms. Li

Chris Bauer as Chief of Surgery (uncredited)

Mark A. Keeton as Guitar Salesman (uncredited)

Sonia Manzano as Lady (uncredited)