Tom Hanks as Lawrence Whatley Bourne III

John Candy as Tom Tuttle

Rita Wilson as Beth Wexler

Tim Thomerson as John Reynolds

Gedde Watanabe as At Toon

George Plimpton as Lawrence Bourne Jr.

Ernest Harada as Chung Mee

Allan Arbus as Albert Bardenaro

Xander Berkeley as Kent Sutcliffe

Ji-Tu Cumbuka as Cicero

Jacqueline Evans as Aunt Eunice

Pamela Gual as Tammy the Stewardess

Chick Hearn as Announcer

Virginia Kiser as Evelyn Bourne

Clyde Kusatsu as Souvanna

Jude Mussetter as Bootsy Winder

Carlos Romano as Beatty

Duncan Ross as Noble

Shakti Chen as Lucille

Professor Toru Tanaka as Sumo Guard

Guillermo Río as Sumo Guard

Lonnie Wun as Sumo Guard

Harry Yorku as Al Pe

Fidel Castro as Self (archive footage) (uncredited)

Doris Day as Self (archive footage) (uncredited)

John Glenn as Self (archive footage) (uncredited)

Rock Hudson as Self (archive footage) (uncredited)

John F. Kennedy as Self (archive footage) (uncredited)

Nikita Khrushchev as Self (archive footage) (uncredited)

Mao Zedong as Self (archive footage) (uncredited)

Marilyn Monroe as Self (archive footage) (uncredited)

Jacqueline Kennedy as Self (archive footage) (uncredited)

John XXIII. as Self (archive footage) (uncredited)

Ed Sullivan as Self (archive footage) (uncredited)