Rose McGowan as Cherry Darling

Freddy Rodríguez as Wray

Marley Shelton as Dr. Dakota Block

Josh Brolin as Dr. William Block

Jeff Fahey as J.T. Hague

Michael Biehn as Sheriff Hague

Bruce Willis as Lieutenant Muldoon

Rebel Rodriguez as Tony Block

Naveen Andrews as Abby

Julio Oscar Mechoso as Romey

Fergie as Tammy Visan

Nicky Katt as Joe

Michael Parks as Earl McGraw

Tom Savini as Deputy Tolo

Carlos Gallardo as Deputy Carlos

Skip Reissig as Skip

Tommy Nix as Paramedic Nixer

Quentin Tarantino as Rapist #1

Gregory Kelly as Rapist #2

Electra Avellan as Babysitter Twin #1

Elise Avellan as Babysitter Twin #2

Felix Sabates as Dr. Felix

Troy Robinson as Soldier #1

Derek Southers as Soldier #2

Jason Douglas as Lewis

Cecilia Conti as Paramedic Cecil

Danny Trejo as Machete

Jerili Romeo as Ramona McGraw

Cheech Marin as Priest

Corey Burton as Additional Narrator (voice)

Emmy Robbin as Hot Female Deputy (uncredited)

Zoë Bell as Sicko Eating Paramedic #2 (uncredited)

Robert Rodriguez as One of Abby's Henchmen (uncredited)